Thermo Fisher Scientific Urokinase Polyclonal Antibody
Thermo Fisher Scientific의 Urokinase Polyclonal Antibody는 사람 단백질에 반응하며 Western blot, IHC, ICC에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, 0.77 mg/mL 농도이며 장기 보관 시 -20°C에서 보관을 권장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 177–425 of Urokinase (Uniprot ID: P00749) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.77 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552142 |
Product Specific Information
- Recommended positive controls: IMR32
- Predicted reactivity: Dog (81%), Pig (82%), Rabbit (85%), Sheep (81%)
- IHC notes: Requires antigen retrieval using heat-mediated 10 mM Citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation.
A specific polymorphism in this gene may be associated with late-onset Alzheimer’s disease and decreased affinity for fibrin-binding.
This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen.
Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative (HMW-uPA), which can be further processed into LMW-uPA.
LMW-uPA remains proteolytically active but does not bind to the uPA receptor.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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