Thermo Fisher Scientific TIP60 Polyclonal Antibody
TIP60 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 IHC에 적합. 인간 및 생쥐 반응성, 항원 친화 크로마토그래피로 정제. DNA 복구 및 전사 조절 연구에 활용 가능.
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Thermo Fisher Scientific TIP60 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 61–292 of TIP60 (Uniprot ID: Q92993) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.67 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2552146 |
Product Specific Information
- Recommended positive controls: Jurkat, Jurkat nucleus
- Predicted reactivity: Mouse (99%), Rat (99%), Pig (99%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TIP60 is a transcription factor originally isolated as an HIV-1 TAT-interactive protein, interacting with the viral TAT protein that leads to HTATIP polyubiquitination and degradation.
It belongs to the MYST family of histone acetyl transferases (HATs) and acts as a catalytic subunit of the NuA4 histone acetyltransferase complex, involved in transcriptional activation of select genes through acetylation of nucleosomal histone H4 and H2A.
TIP60 functions as a co-regulator of transcription factors, influencing tumorigenesis, DNA repair, and apoptosis, and plays an important role in signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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