Thermo Fisher Scientific LRP1 Monoclonal Antibody (A2Mr alpha-2)
인간 LRP1(CD91)을 인식하는 mouse monoclonal antibody로, WB, IHC, ICC, Flow, ELISA, IP 등 다양한 응용에 적합합니다. 비결합형 액상 포맷이며, Protein A 정제 및 1 mg/mL 농도로 제공됩니다. 알츠하이머 관련 연구에 활용 가능합니다.
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- MA180192
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2Mr alpha-2 |
| Immunogen | Purified alpha2 macroglobulin receptor (LRP1/CD91, UniProt ID: Q07954-1, antigen range: 1–4544) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_929727 |
Product Specific Information
MA1-80192 recognizes human CD91, also known as alpha-2 macroglobulin receptor (alpha2 MR). It binds to an epitope in the extracellular region of the 500 kDa alpha chain.
A suggested positive control for immunohistochemistry is liver tissue.
Non-reducing conditions are recommended for Western blot applications.
For flow cytometry, use 10 µL of the recommended dilution to label 1×10⁶ cells in 100 µL.
Target Information
The LRP1 (CD91) protein is an endocytic receptor involved in intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It plays a role in A2M-mediated clearance of amyloid precursor protein and beta-amyloid, key components of amyloid plaques in Alzheimer’s disease. Expression decreases with age and is reduced in Alzheimer’s patient brain tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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