Thermo Fisher Scientific CRISP2 Polyclonal Antibody
CRISP2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 사용 가능. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, 냉장 또는 냉동 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide near the amino terminus of human CRISP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153782 |
Product Specific Information
- A suggested positive control is human testis tissue lysate.
- PA5-21007 can be used with blocking peptide PEP-1121.
Target Information
The cysteine-rich secretory proteins (CRISP) family is a group of four proteins strongly expressed in the male reproductive tract and implicated in male fertility.
CRISP2 (also known as TPX1) is involved in adhesion between spermatids and Sertoli cells and, along with CRISP1, may play a role in sperm-egg fusion.
It regulates Ca²⁺ influx through ryanodine receptors (RYR) and may influence the acrosome reaction or sperm motility.
CRISP2 also binds to mitogen-activated protein kinase kinase kinase 11 (MAP3K11) and localizes to the developing acrosome, suggesting a role in acrosome development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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