Thermo Fisher Scientific HVCN1 Polyclonal Antibody
HVCN1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품. 2–8°C 보관, 장기 보관 시 -20°C 권장.
- 카탈로그번호
- PA521008
- 판매단위
- pk
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Thermo Fisher Scientific HVCN1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1.0 µg/mL | - |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the carboxy terminus of human HVCN1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153744 |
Product Specific Information
A suggested positive control is human spleen tissue lysate.
PA5-21008 can be used with blocking peptide PEP-1122.
Target Information
HVCN1 (hydrogen voltage-gated channel 1) is a voltage-gated proton channel protein highly expressed in immune tissues.
It mediates proton conductance required by phagocytic leukocytes for the oxidative burst that underlies microbial killing.
HVCN1 moderates voltage-dependent proton permeability of excitable membranes, allowing proton flow according to their electrochemical gradient.
It is sensitive to zinc ions and can be inhibited by them.
HVCN1 may represent a new therapeutic target for B cell malignancies involving continued signaling via the B cell antigen receptor.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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