Thermo Fisher Scientific TIP47 Polyclonal Antibody
TIP47 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능하며, Human 및 Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상형 항체로 연구용에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the carboxy terminus of human TIP47 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152062 |
Product Specific Information
A suggested positive control is Daudi cell lysate.
PA5-20272 can be used with blocking peptide PEP-0387.
Target Information
TIP47 has been described as a cargo protein involved in trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex.
The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome-to-Golgi transport.
This protein also binds directly to the GTPase RAB9, a member of the RAS oncogene family. The interaction with RAB9 increases the affinity of this protein for its cargo.
TIP47 has been localized in milk fat globule membranes of human and bovine origin and described as a placental protein. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients, suggesting its potential role as an oncodevelopmental marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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