Thermo Fisher Scientific CACNA1A/Cav2.1 Polyclonal Antibody
Rabbit polyclonal antibody targeting CACNA1A (Cav2.1) for IHC, ICC, and ELISA applications. Recognizes human, mouse, and rat. Protein A purified, 1 mg/mL in TBS buffer with BSA and glycerol. Suitable for neuroscience and calcium channel research.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CACNA1A (amino acids 1401–1500) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Voltage-dependent calcium channels mediate calcium ion entry into excitable cells and are involved in processes such as muscle contraction, hormone or neurotransmitter release, and gene expression. These channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The alpha-1 subunit forms the pore and determines channel properties.
The CACNA1A gene encodes the alpha-1A subunit, primarily expressed in neuronal tissue. Mutations in this gene are associated with familial hemiplegic migraine and episodic ataxia type 2. Polymorphic variations due to n-repeats can lead to spinocerebellar ataxia type 6 when expanded in the coding region.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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