Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/8790)
RET 단백질을 인식하는 마우스 단클론 항체로, IHC(P)에서 1-2 µg/mL 농도로 사용 가능. 인간 시료에 반응하며, 단백질 A/G로 정제된 액상형 제품. 4°C에서 보관하며, RET 관련 암 연구에 적합.
- 카탈로그번호
- 5979-MSM15-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/8790)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RET/8790 |
| Immunogen | Recombinant fragment (around aa 702–848) of human RET protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Colon or prostate carcinoma, human breast tissue
- Cellular Location: Membrane
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. It transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma.
Two transcript variants encoding different isoforms have been found for the RET gene, with additional variants described but not yet biologically confirmed.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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