Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/2599)
RET 단백질을 표적으로 하는 mouse monoclonal antibody로 인간 시료에 반응합니다. ELISA 및 peptide array에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 신경능선 발달 및 종양 관련 RET 연구에 적합합니다.
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Applications
ELISA (ELISA)
- Tested Dilution: 2–4 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RET/2599 |
| Immunogen | Recombinant fragment (around aa 702–848) of human RET protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. RET transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma.
Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET, but their biological validity has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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