Thermo Fisher Scientific RET Proto-oncogene Monoclonal Antibody (RET/8787)
RET 단백질을 표적하는 마우스 단클론 항체로, IHC(P)에서 1–2 µg/mL 농도로 사용 가능. 인간 시료에 반응하며, 단백질 A/G로 정제된 액상 형태. 양성 대조군으로 결장암 또는 전립선암 조직에 적합. 세포막에 발현된 RET 단백질 검출에 유용.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RET/8787 |
| Immunogen | Recombinant fragment (around aa 702–848) of human RET protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Colon or prostate carcinoma, human breast tissue
- Cellular Location: Membrane
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily. RET plays a crucial role in neural crest development and can undergo oncogenic activation by cytogenetic rearrangement. RET transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been identified, with additional variants described but not fully validated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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