Thermo Fisher Scientific CYP11A1 Polyclonal Antibody
Thermo Fisher Scientific의 CYP11A1 폴리클로날 항체는 인간 CYP11A1 단백질을 인식하며, 면역조직화학(IHC) 등 연구용 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었고, 액상 형태로 제공되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human CYP11A1. Recombinant protein control fragment (Product #RP-91064). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856223 |
Product Specific Information
Immunogen sequence:
RSVLVKGCQT FLSAPREGLG RLRVPTGEGA GISTRSPRPF NEIPSPGDNG WLNLYHFWRE TGTHKVHLHH VQNFQKYGPI YREKLGNVES VYVIDPEDVA LLFKSEGPNP ERFLIPPWVA YHQYYQRPIG VLLKKSAA
Target Information
CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc, and cytochrome P450 subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signaling.
CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, regulated by hormonal control of cholesterol availability.
Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site is required for hormonal stimulation.
c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in interstitial cell monolayers with functional adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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