Thermo Fisher Scientific GLRA1 Polyclonal Antibody
GLRA1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 인간 시료 반응성, IHC(P) 적용 가능, 항원 친화 크로마토그래피로 정제됨. 연구용으로 신경계 억제성 글라이신 수용체 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human GLRA1. Recombinant protein control fragment (Product #RP-91080) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856224 |
Product Specific Information
Immunogen Sequence:
LLRFRRKRRH HKEDEAGEGR FNFSAYGMGP ACLQAKDGIS VKGANNSNTT NPPPAPSKSP EEMRKLFIQR AKKIDK
Target Information
GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system.
Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.
Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine.
GLRA1 is widely distributed throughout the CNS, particularly within the hippocampus, spinal cord, and brain stem.
Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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