Thermo Fisher Scientific GLRA1 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))
  Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Immunogen Sequence:
LLRFRRKRRH HKEDEAGEGR FNFSAYGMGP ACLQAKDGIS VKGANNSNTT NPPPAPSKSP EEMRKLFIQR AKKIDK

Target Information

GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system.
Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome.
Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine.
GLRA1 is widely distributed throughout the CNS, particularly within the hippocampus, spinal cord, and brain stem.
Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.