Thermo Fisher Scientific KCNQ5 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20–1:50

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
LALASFQIPP FECEQTSDYQ SPVDSKDLSG SAQNSGCLSR STSANISRGL QFILTPNEFS AQTFYALSPT MHSQATQVPI SQSDGSAVAA TNTIANQINT APKPAAPTTL QIPPPL

Target Information

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently, there are five known KCNQs (KCNQ1–5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain, and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.