Thermo Fisher Scientific UNC5A Polyclonal Antibody

Thermo Fisher Scientific UNC5A Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
VSPSTSDLACK LWVWQVEGDG QSFSINFNIT KDTRFAELLA LESEAGVPAL VGPSAFKIPF LIRQKIIS

Highest antigen sequence identity to the following orthologs:

• Mouse: 90%
• Rat: 90%

Target Information

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. When cleaved by a caspase to produce an intracellular fragment containing a death domain, UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1.

In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion. Mutation of these receptors may contribute to tumorigenicity. Expression of UNC5H receptors is downregulated in various carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers.

UNC5H1 (UNC5HA, unc-5 homolog A) is a member of the UNC5H family, localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.