Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Synaptotagmin 1 단백질을 인식하는 sheep 유래 polyclonal 항체. WB 및 IHC에 적합하며, 신경전달 및 시냅스 소포 연구에 활용 가능. 동결건조 형태로 제공되며, 장기보관 시 -20°C에서 안정적. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 10–50 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 10–50 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse Synaptotagmin 1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10709563 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute in 500 µL of sterile water.
- The peptide is homologous in rat and human.
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS and acts as a Ca²⁺ sensor in exocytosis and neurotransmitter release.
Its Ca²⁺-mediated binding of SNAP25 is essential for Ca²⁺-dependent membrane triggering.
Specific residues within the C2B domain regulate endocytic rate and vesicle size.
Synaptotagmin 1 may play a role in synaptic vesicle trafficking and binds acidic phospholipids requiring both an acidic head group and diacyl backbone.
It interacts with receptors for activated protein kinase C in a Ca²⁺-dependent manner and also binds neurexins, syntaxin, and AP2 independently of Ca²⁺.
Dysfunction of Synaptotagmin 1 is associated with food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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