Thermo Fisher Scientific Synaptotagmin1 Polyclonal Antibody
Synaptotagmin 1 단백질을 인식하는 sheep 유래 polyclonal antibody. WB 및 IHC에 사용 가능하며, mouse와 rat에 반응. Lyophilized 형태로 제공되며, 장기 보관 시 -20°C에서 안정적. 신경전달물질 방출 및 시냅스 소포 조절 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse Synaptotagmin 1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and human.
- Specificity of this antibody: SYTI.
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS. It acts as a Ca²⁺ sensor in exocytosis and neurotransmitter release regulation. Studies show its Ca²⁺-mediated SNAP25 binding is essential for Ca²⁺-dependent membrane triggering.
Discrete residues within the C2B binding domain independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may regulate membrane interactions during synaptic vesicle trafficking at the active zone.
It binds acidic phospholipids requiring both an acidic head group and diacyl backbone. Ca²⁺-dependent interaction occurs with receptors for activated protein kinase C, and Ca²⁺-independent binding with neurexins, syntaxin, and AP2.
Dysfunction of Synaptotagmin 1 is associated with food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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