Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (508A3H12), Biotin
인간 IL-1β를 인식하는 Mouse IgG1 단일클론 항체로, Biotin 결합형입니다. ELISA 등 면역분석에 적합하며, 단백질 A 정제 및 안정적인 PBS/BSA 완충액에 보관됩니다. 염증성 사이토카인 연구용으로 사용됩니다.
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Applications
- ELISA (Assay-dependent)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 508A3H12 |
| Immunogen | Recombinant human IL-1-beta |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 5 mg/mL BSA |
| Contains | 0.5 mg/mL sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2536251 |
Product Specific Information
This clone can also be referred to as clone number 508A 3H12 G4 R2.
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and becomes active (17 kDa) upon cleavage by caspase-1 following inflammasome activation. IL-1β is secreted via a non-classical pathway and signals through IL-1RI and IL-1RII receptors, shared with IL-1α. Its activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which competitively inhibits receptor binding. IL-1β plays a critical role in innate immune defense and inflammation, and elevated levels are associated with chronic inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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