Thermo Fisher Scientific SIGIRR Recombinant Rabbit Monoclonal Antibody (010)

Thermo Fisher Scientific SIGIRR Recombinant Rabbit Monoclonal Antibody (Clone 010)

Applications

• Flow Cytometry (Flow)

Tested Dilution: 1:25–1:100
Publications: – (No references listed)

Product Specifications

Additional Formats

• PE Conjugate (MA5-40972)
• Request Custom Conjugation

Target Information

SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both.
SIGIRR has only one Ig domain in its extracellular portion, whereas the IL-1R family contains three Ig folds. Its unusually long cytoplasmic domain resembles the structure of Drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI.
A chimera in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain did not activate NFκB, unlike similar fusion proteins of other IL-1R-related molecules. Phylogenetic data suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.