Thermo Fisher Scientific SIGIRR Recombinant Rabbit Monoclonal Antibody (010)
인간 SIGIRR 단백질을 인식하는 재조합 토끼 단클론 항체로, Flow Cytometry에 최적화됨. HEK293 세포에서 발현되며 Protein A로 정제된 액상 형태. 보존제가 없으며 단기 4°C, 장기 -20°C에서 안정적으로 보관 가능.
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Thermo Fisher Scientific SIGIRR Recombinant Rabbit Monoclonal Antibody (Clone 010)
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:25–1:100
Publications: – (No references listed)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 010 |
| Immunogen | Recombinant Human SIGIRR/TIR8 Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866636 |
Additional Formats
Target Information
SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both.
SIGIRR has only one Ig domain in its extracellular portion, whereas the IL-1R family contains three Ig folds. Its unusually long cytoplasmic domain resembles the structure of Drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI.
A chimera in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain did not activate NFκB, unlike similar fusion proteins of other IL-1R-related molecules. Phylogenetic data suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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