Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (19C7)
Cardiac Troponin I 단백질 검출용 단클론 항체. Western blot, IHC, ELISA 등 다양한 응용에 적합. Human, Mouse 등 여러 종에 반응. Protein A로 정제된 고순도 항체로 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 4 publications |
| Immunohistochemistry (IHC) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Affinity Purification (AP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Cat, Fish, Goat, Human, Mouse, Pig, Rabbit, Rat |
| Published Species | Human, Mouse |
| Host/Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 19C7 |
| Immunogen | Native troponin complex |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.7 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_2206410 |
Product Specific Information
MA1-22700 detects Cardiac Troponin I in Human, Mouse, Rat, Bovine, Feline, Canine, Fish, Porcine, Goat, and Rabbit samples.
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that forms part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit binds to tropomyosin to form a troponin-tropomyosin complex, anchored by the binding of TnI to actin within muscle thin filaments. When calcium binds to specific sites on the regulatory TnC subunit, it induces a structural change that releases the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels is an important diagnostic indicator of cardiac muscle damage and helps differentiate between angina and myocardial infarction. Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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