Thermo Fisher Scientific Phospho-Jak3 (Tyr980, Tyr981) Recombinant Rabbit Monoclonal Antibody (JAK3Y980981-E10), APC
APC 형광으로 표지된 인산화 Jak3(Tyr980/981) 특이 재조합 토끼 단클론 항체. 인간 시료에 반응하며 Flow Cytometry에 적합. HEK293 발현 시스템, Protein A/G 정제, PBS+BSA 저장. 연구용으로만 사용 가능.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JAK3Y980981-E10 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr980/981 of human Jak3 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897137 |
Additional Formats
Target Information
Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family.
JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors.
In response to various cytokines or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at two adjacent tyrosine residues.
Activated JAKs phosphorylate STAT proteins, which dimerize and translocate to the nucleus to modify transcription of numerous genes, including interferon-stimulated genes.
JAK2 is required for the IFN gamma-receptor complex initiation, and JAK1 functions as an amplifier. Some studies suggest JAK2’s role may be substituted by Tyk2 and JAK3 under specific conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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