Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody
Phospho-SCNN1B (Ser633) 특이적 Rabbit Polyclonal Antibody로 IHC에 최적화됨. Mouse 및 Rat 반응성. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. SCNN1B 단백질의 인산화된 Ser633 부위를 인식하여 나트륨 채널 연구에 활용 가능.
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Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide to phospho S633 of rat amiloride-sensitive sodium channel subunit beta (SCNN1B, SCNEB) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous with the corresponding sequence in mouse.
- Specificity: SCNN1B.
Target Information
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and osmotically coupled water) through epithelial apical membranes. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception.
Forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B cause autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350], a rare salt-wasting disease. Also associated with Liddle syndrome, an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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