Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody

Thermo Fisher Scientific Phospho-SCNN1B (Ser633) Polyclonal Antibody

Applications and Tested Dilution

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Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The antigen is homologous with the corresponding sequence in mouse.
• Specificity: SCNN1B.

Target Information

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and osmotically coupled water) through epithelial apical membranes. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception.

Forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.

Defects in SCNN1B cause autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350], a rare salt-wasting disease. Also associated with Liddle syndrome, an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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