Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI1G7), TrueMAB
COMMD1 단백질을 표적으로 하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot, IHC, ICC/IF, Flow Cytometry에 적합. 고순도 친화 크로마토그래피 정제, 무보존제 PBS 버퍼, 동결건조 형태로 제공. 연구용 전용.
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Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI1G7), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G7 |
| Immunogen | Full length human recombinant protein of human COMMD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
COMMD1 is a proposed scaffold protein involved in diverse physiological processes, including regulation of ubiquitination of specific cellular proteins. It modulates activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, promotes ubiquitination and degradation of NF-kappa-B subunit RELA, and down-regulates NF-kappa-B activity.
It regulates membrane expression and ubiquitination of SLC12A2, modulates Na⁺ transport in epithelial cells via ENaC subunit regulation, and promotes CFTR surface expression. COMMD1 also affects copper ion homeostasis, facilitating ATP7A trafficking and biliary copper excretion. Additionally, it binds phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and regulates HIF1A-mediated transcription.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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