Thermo Fisher Scientific OGG1 Polyclonal Antibody
Thermo Fisher Scientific의 OGG1 Polyclonal Antibody는 인간, 생쥐, 랫드 등 다양한 종에서 반응하며, Western blot, IHC, ICC/IF 등 다중 응용에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, DNA 손상 복구 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 5 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:25–1:100 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
| Flow Cytometry (Flow) | Assay-dependent | – |
| Immunoprecipitation (IP) | 1:10–1:500 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide derived from human Ogg1 (amino acids 1–100, UniProt# O15527) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2156790 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. coli, three DNA repair enzymes prevent the mutagenic effects of 8-hydroxyguanine. One of these, MutM, has functional yeast (yOgg1) and human (hOgg1) homologues.
Human OGG1 proteins efficiently release 8-hydroxyguanine opposite pyrimidine from DNA and cleave the AP site similarly to bacterial and yeast enzymes.
Genetic backgrounds controlling DNA repair are involved in cancer susceptibility. The hOgg1 gene is mapped to region 3p26.2, showing loss of heterozygosity (LOH) in multiple cancers, particularly in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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