Thermo Fisher Scientific HAP40 Polyclonal Antibody
HAP40 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. 마우스 샘플에서 HAP40 검출에 사용되며, 비결합형 액상 형태로 제공됩니다. 헌팅턴 단백질 연구 및 신경퇴행성 질환 연구에 유용합니다.
- 카탈로그번호
- PA131439
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A partial peptide made to the 40 kDa mouse HAP40 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1957654 |
Product Specific Information
PA1-31439 detects HAP40 from mouse samples.
Target Information
Huntington's disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the Huntington protein. Huntington co-purifies with a single novel 40 kDa protein designated HAP40. Recombinant HAP40 is cytoplasmic in the presence of Huntington but is actively targeted to the nucleus in the absence of Huntington. These observations suggest that HAP40 contributes to the function of normal Huntington and is a candidate for involvement in the aberrant nuclear localization of mutant Huntington found in degenerating neurons in Huntington's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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