Thermo Fisher Scientific LIMP2 Polyclonal Antibody
LIMP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종에서 반응하며 WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. KLH 결합 펩타이드 면역원으로 제작된 비결합 항체. 연구용으로만 사용.
- 카탈로그번호
- PA131401
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25 |
| Immunocytochemistry (ICC/IF) | 1:25–1:100 |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Hamster, Human, Mustelid, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide containing residues from mouse SR-BII (between residues 400–478) plus an N-terminal cysteine coupled to KLH. [UniProt# O35114] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1960596 |
Product Specific Information
Product purified by whole antiserum.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with risk for atherosclerosis.
SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene. SR-BII differs from SR-BI in that its encoded C-terminal cytoplasmic domain is almost completely different.
SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, including liver, adrenal glands, and testes.
Although the role of SR-BII is not completely clear, research suggests that it may function as an HDL receptor. SR-BII mRNA results from alternative splicing of SR-BI precursor transcripts, with the SR-BII isoform mediating selective lipid transfer between HDL and cells.
The relative expression and functional activities of these two isoforms may regulate selective lipid transfer between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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