Thermo Fisher Scientific PABPN1 Polyclonal Antibody
PABPN1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot과 면역세포화학에 적합하며, 인간, 마우스 등 다양한 종과 반응. 합성 펩타이드 면역원으로 제작, 고순도 친화 크로마토그래피 정제. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.25 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human PABPN1 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607006 |
Product Specific Information
Peptide sequence:
MAAAAAAAAA AGAAGGRGSG PGRRRHLVPG AGGEAGEGAP GGAGDYGNGL
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Human: 100%
Mouse: 93%
Rabbit: 100%
Rat: 93%
Target Information
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3′ ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt.
At steady-state, this protein is localized in the nucleus, whereas a different poly(A) binding protein is localized in the cytoplasm.
This gene contains a GCG trinucleotide repeat at the 5′ end of the coding region, and expansion of this repeat from the normal 6 copies to 8–13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD).
Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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