Thermo Fisher Scientific GPR68 Recombinant Rabbit Monoclonal Antibody (16H23L16)
GPR68 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 IHC에 사용 가능. 높은 특이성과 재현성을 제공하며, Expi293 시스템에서 발현됨. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (IHC) | 1:500 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 16H23L16 |
| Immunogen | Peptide corresponding to human GPR68 (aa342–aa365) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784550 |
Product Specific Information
This antibody is predicted to react with Monkey, Rat, Mouse, and Horse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and the best-performing clones are selected for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1)
GPR68 is a proton-sensing receptor involved in pH homeostasis and acts as an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. It mediates its action via G proteins that stimulate inositol phosphate (IP) production or Ca²⁺ mobilization. The receptor is nearly silent at pH 7.8 but fully activated at pH 6.8. It also functions as a tumor suppressor in prostate cancer. Mutations in this gene can cause amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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