Thermo Fisher Scientific CD23 Monoclonal Antibody (B3B4), PE, eBioscience

Thermo Fisher Scientific CD23 Monoclonal Antibody (B3B4), PE, eBioscience

Applications and Tested Dilution

Product Specifications

Available Formats

• Unconjugated
• Biotin
• Brilliant UV 805
• eFluor 450
• eFluor 660
• FITC
• NovaFluor Blue 510
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Red 685
• NovaFluor Red 710
• NovaFluor Red 725
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• NovaFluor Yellow 755
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Super Bright 645
• Request custom conjugation available

Product Specific Information

The B3B4 monoclonal antibody reacts with mouse CD23, a 45 kDa type II transmembrane glycoprotein expressed on resting conventional B cells. Expression is modulated upon B-cell activation, while CD5+ B-1 cells do not express CD23. Soluble forms of CD23 are biologically active and serve as low-affinity receptors for IgE, playing a role in IgE response regulation and B-cell activation. CD21 is thought to bind CD23.

Applications Reported: Flow cytometric analysis.
Applications Tested: Tested on mouse splenocytes at ≤0.125 µg/test (100 µL final volume). Optimal titration recommended.
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green lasers
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD23 is a 45 kDa glycoprotein found on a subpopulation of peripheral blood and tonsil B cells and highly expressed on EBV-transformed B lymphoblasts. It is identical to the low-affinity IgE receptor on B cells and is involved in B cell growth, differentiation, and IgE production. Soluble CD23 acts as a mitogenic factor. CD23 expression is associated with B cell chronic lymphocytic leukemia and certain lymphomas. Dysfunction of CD23 may be linked to chronic conjunctivitis and chronic lymphocytic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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