Thermo Fisher Scientific Involucrin Recombinant Rabbit Monoclonal Antibody (IVRN, 2113R)
Recombinant rabbit monoclonal antibody recognizing Involucrin in human, dog, pig, and primate tissues. Optimized for IHC (paraffin) with high specificity and no cross-reactivity with mouse. Supplied as 200 µg/mL liquid, purified by Protein A/G, stored ...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Non-human primate, Pig |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | IVRN, 2113R |
| Immunogen | Recombinant human full-length Involucrin protein (IVRN) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- This antibody does not react with Mouse.
- For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- For staining of formalin-fixed tissues: heat tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
Involucrin is a component of the keratinocyte crosslinked envelope, found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. It is expressed in stratified squamous epithelia, including the cornea, and first appears in the upper spinous layers of normal epidermis. In keratinocyte cultures, it is expressed by all cells that have left the basal layer.
Abnormal expression of Involucrin is observed in squamous cell carcinomas and premalignant lesions, and reduced expression occurs in severe dysplasias of the larynx and cervix. The gene is mapped to chromosome 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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