Thermo Fisher Scientific Phospho-DNA PK/PRKDC (Ser2056) Polyclonal Antibody
DNA-PK/PRKDC (Ser2056) 인산화 부위를 인식하는 rabbit polyclonal antibody. 인간, 마우스, 랫트 반응성. IHC, ICC/IF, ELISA 등 다양한 응용 가능. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human DNA-PK around the phosphorylation site of Ser2056 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and is often inhibited by small molecules targeting PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for the expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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