Thermo Fisher Scientific TIE2 (TEK) Polyclonal Antibody
TIE2(TEK) 단백질을 표적하는 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응합니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, 재구성 후 500 µg/mL 농도로 사용 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human TIE2 recombinant protein (Position: Q641–I830) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2747218 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
The TEK receptor tyrosine kinase (also known as TIE2) is expressed almost exclusively in endothelial cells. TEK signaling is essential for endothelial cell–smooth muscle cell communication during venous morphogenesis, and defects in TEK are linked to inherited venous malformations.
Angiopoietin-1 binds to TEK and mediates a signaling pathway important for embryonic vascular development.
Immunoblotting studies show that TIE2 expression increases in response to thyroid-stimulating hormone and agents that elevate intracellular cAMP.
Hematopoietic stem cells (HSCs) expressing TIE2 are quiescent, antiapoptotic, and form a side population that adheres to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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