Thermo Fisher Scientific TERT Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• The synthetic peptide sequence is 15–30 aa: RSRYREVWPLATFVRR
• Add 0.2 mL of distilled water to reconstitute, yielding a concentration of 500 µg/mL.

Target Information

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by adding the telomere repeat TTAGGG.
The enzyme consists of a protein component with reverse transcriptase activity, encoded by the TERT gene, and an RNA component that serves as a template for telomere repeat synthesis.
Telomerase expression is typically repressed in postnatal somatic cells, leading to progressive telomere shortening and cellular senescence.
Deregulation of telomerase expression may contribute to oncogenesis.
In mice, telomerase also participates in chromosomal repair, as de novo synthesis of telomere repeats may occur at double-stranded breaks.
Alternative splicing of TERT generates multiple isoforms, which may regulate telomerase activity.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.