Thermo Fisher Scientific HLA-DRB1 Recombinant Rabbit Monoclonal Antibody (ARC2360)

Thermo Fisher Scientific HLA-DRB1 Recombinant Rabbit Monoclonal Antibody (ARC2360)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Samples: HeLa, Raji
• Immunogen sequence:
  ARAAVDTYCR HNYGVVESFT VQRRVQPKVT VYPSKTQPLQ HHNLLVCSVS GFYPGSIEVR WFLNGQEEKA GMVSTGLIQN GDWTFQTLVM LETVPRSGEV Y

Target Information

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33–35 kDa and its gene contains five exons:

1. Exon 1 encodes the leader peptide
2. Exons 2 and 3 encode the two extracellular domains
3. Exon 4 encodes the transmembrane domain and the cytoplasmic tail

DRA does not have polymorphisms in the peptide-binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.

HLA and MHC antibodies play a significant role in immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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