Thermo Fisher Scientific HLA-DRB1 Recombinant Rabbit Monoclonal Antibody (ARC2360)
Human HLA-DRB1 단백질을 표적하는 재조합 토끼 모노클로날 항체로, WB, IHC, ELISA 등에 사용 가능. HEK293 세포에서 발현되며 높은 특이성과 재현성을 제공. 연구용으로 면역펩티도믹스 및 항원 제시 연구에 적합.
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Thermo Fisher Scientific HLA-DRB1 Recombinant Rabbit Monoclonal Antibody (ARC2360)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2360 |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human HLA-DRB1 (P01911) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.28 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.3) with 0.05% BSA and 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897948 |
Product Specific Information
- Positive Samples: HeLa, Raji
- Immunogen sequence:
ARAAVDTYCR HNYGVVESFT VQRRVQPKVT VYPSKTQPLQ HHNLLVCSVS GFYPGSIEVR WFLNGQEEKA GMVSTGLIQN GDWTFQTLVM LETVPRSGEV Y
Target Information
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.
Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33–35 kDa and its gene contains five exons:
- Exon 1 encodes the leader peptide
- Exons 2 and 3 encode the two extracellular domains
- Exon 4 encodes the transmembrane domain and the cytoplasmic tail
DRA does not have polymorphisms in the peptide-binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
HLA and MHC antibodies play a significant role in immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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