Thermo Fisher Scientific AKR1C2 Polyclonal Antibody
AKR1C2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간 단백질에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 보장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AKR1C2 (Accession P52895), corresponding to amino acid residues E28–D78 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850850 |
Product Specific Information
Antibody detects endogenous levels of total AKR1C2.
Target Information
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2.
AKR1C3 and 3 alpha-HSD are alternate designations for human DD3 (AKR1C18 in rodents), while DD4 can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents).
DD1 and DD2 are 20 alpha-HSDs, whereas DD3 and DD4 are the 3 alpha-HSDs.
The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics such as polycyclic aromatic hydrocarbons, pesticides, and steroid hormones, and are responsible for the reduction of ketone-containing drugs using NADH or NADPH as cofactors.
The 20 alpha-HSD catalyzes the reaction of progesterone to the inactive form 20 alpha-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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