Thermo Fisher Scientific Phospho-Myc (Thr358) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a crucial role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is associated with cell proliferation and regulation. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, while deregulated expression induces apoptosis in diverse cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to target proteins.

Amplification of the c-Myc gene has been observed in lung, breast, and colon carcinomas; N-Myc amplification occurs in neuroblastomas. Chromosomal translocations involving c-myc are characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-myc expression is found in tumors of various origins, including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.