Thermo Fisher Scientific Phospho-Elk1 (Thr417) Polyclonal Antibody
Phospho-Elk1 (Thr417) 폴리클로날 항체로, 인간·마우스·랫트 반응성을 가지며 IHC 및 ICC/IF에 사용 가능. MAP kinase 경로의 ELK1 인산화 연구에 적합. Protein A로 정제된 액상 항체로 -20°C 보관.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:100
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence that includes phosphorylation site of threonine 417 (L-S-T(p)-P-V) derived from human Elk1 and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors.
It is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus.
Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1.
ELK1 acts as a nuclear target for the ras-raf-MAPK signaling cascade.
Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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