Thermo Fisher Scientific Leptin Receptor Polyclonal Antibody
Leptin 수용체(OB-R)를 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot, IHC, Flow cytometry 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 반응성. 합성 펩타이드 항원 기반으로 제작, 0.5 mg/mL 농도의 액상 형태로 제공.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Leptin Receptor Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–6 µg/mL | – |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Flow Cytometry (Flow) | 10 µg/mL | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (TQDDIEKHQSDAG) corresponding to internal amino acids of LEPR (aa 829–841) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10977531 |
Product Specific Information
- Predicted to react with canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily and plays a key role in mammalian body weight homeostasis and energy balance. Activation by leptin triggers downstream signaling through the JAK/STAT pathway. Several isoforms of OB-R exist, differing in length and signaling capability. The long form is expressed in the choroid plexus and hypothalamus, proposed as centers for satiety and energy expenditure.
Mutations in mouse OB-R (db) or leptin (ob) genes lead to early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.