Thermo Fisher Scientific IGF2BP3 Recombinant Rabbit Monoclonal Antibody (8K4H5)
Thermo Fisher Scientific IGF2BP3 항체는 인간 IGF2BP3 단백질을 인식하는 재조합 토끼 모노클로날 항체로, WB, IHC, ELISA에 사용 가능. HEK293 세포에서 발현되며 Affinity Chromatography로 정제됨. 암 연구 및 단백질 발현 분석에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8K4H5 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 2–194 of human IMP3 (O00425) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911957 |
Product Specific Information
- Positive test controls include: 293T, HepG2, A-549
- Immunogen sequence:
NKLYIGNLSE NAAPSDLESI FKDAKIPVSG PFLVKTGYAF VDCPDESWAL KAIEALSGKI ELHGKPIEVE HSVPKRQRIR KLQIRNIPPH LQWEVLDSLL VQYGVVESCE QVNTDSETAV VNVTYSSKDQ ARQALDKLNG FQLENFTLKV AYIPDEMAAQ QNPLQQPRGR RGLGQRGSSR QGSPGSVSKQ KPC
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is expressed in a significantly higher proportion of melanomas than Spitz nevi and in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in regulating the biological behavior of this tumor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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