Thermo Fisher Scientific CD122 Monoclonal Antibody (27302)

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

8-25 µg/mL

-

Flow Cytometry (Flow)

2.5 µg per million cells

-

Neutralization (Neu)

0.05-0.15 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

27302

Immunogen

Sf 21-derived recombinant human IL-2 R beta Ala27-Asp239 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD122,uniProtId:P14784-1,ncbiNodeId:9606,antigenRange:27-239,antigenLength:551,antigenImageFileName:MA5-23816_CD122_P14784-1_House_mouse.svg,antigenImageFileNamePDP:MA5-23816_CD122_P14784-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609411

Product Specific Information

In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R alpha, rh gamma c, rhIL-4 R, or rhIL-6 R is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and is present in 3 forms. The low affinity form of CD122 is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from CD122. The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein. Diseases associate with CD122 protein dysfunction include oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.