Thermo Fisher Scientific CD122 Monoclonal Antibody (27302)
CD122 단클론 항체로 인간 IL-2 수용체 베타 사슬을 인식합니다. IHC, Flow Cytometry, Neutralization 등 다양한 응용에 사용됩니다. Protein A/G로 정제된 동결건조 형태이며, 보존제가 없고 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 8–25 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
| Neutralization (Neu) | 0.05–0.15 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 27302 |
| Immunogen | Sf21-derived recombinant human IL-2R beta (Ala27–Asp239) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609411 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant human IL-2R alpha, gamma c, IL-4R, or IL-6R is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
CD122 (Interleukin-2 receptor beta chain) participates in T cell-mediated immune responses and is primarily expressed in the hematopoietic system.
It exists in three forms:
- Low affinity: Alpha subunit monomer, not involved in signal transduction
- Intermediate affinity: Alpha/beta heterodimer
- High affinity: Alpha/beta/gamma heterotrimer
Intermediate and high affinity forms are responsible for receptor-mediated endocytosis and mitogenic signal transduction.
The beta subunit encoded by the CD122 gene is a type I membrane protein.
Dysfunction of CD122 is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor-negative juvenile idiopathic arthritis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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