Thermo Fisher Scientific HMHA1/HA-1 Polyclonal Antibody
Human HA-1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Assay-dependent
- Immunoprecipitation (IP): 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25–75 of human Minor histocompatibility protein HA-1 (Cleaved into: Minor histocompatibility antigen HA-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This protein contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that negatively regulates the actin cytoskeleton and cell spreading. It also includes an N-terminal BAR-domain that exerts an autoinhibitory effect on RhoGAP activity.
HA-1 is a precursor of the histocompatibility antigen HA-1, a minor histocompatibility antigen (mHag) that can elicit immune responses when presented by MHC molecules. These peptides, derived from polymorphic intracellular proteins, can trigger graft rejection or graft-versus-host disease (GVHD) after HLA-identical bone marrow transplantation.
Mismatch of mHag HA-1 is associated with severe GVHD, and HA-1 is presented by MHC class I HLA-A*0201 and other HLA-A alleles, eliciting donor cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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