Thermo Fisher Scientific ERLIN2 Polyclonal Antibody
ERLIN2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB, IHC, ICC/IF 등 다양한 응용 가능. 인간, 생쥐, 랫트 반응성 보유. 항원 친화 크로마토그래피로 정제되었으며, 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific ERLIN2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ERLIN2. Recombinant protein control fragment (Product #RP-95924) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641111 |
Product Specific Information
Immunogen sequence:
KTKLLIAAQK QKVVEKEAET ERKKALIEAE KVAQVAEITY GQKVMEKETE KKISEIEDAA FLAREKAKAD AECYTAMKIA EANKLKLTPE YLQLMKYKAI ASNSKIYFGK DIPNMFMDSA GSVSKQFEGL ADKLSFGLED EPLETATK
Highest antigen sequence identity to the following orthologs:
- Mouse: 94%
- Rat: 95%
Target Information
ERLIN2, also known as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex that mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1.
It promotes sterol-accelerated ERAD of HMGCR, likely involving an AMFR/gp78-containing ubiquitin ligase complex.
ERLIN2 regulates cellular cholesterol homeostasis via the SREBP signaling pathway.
The molecular weight of the ERLIN1/ERLIN2 complex is approximately 70 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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