Thermo Fisher Scientific Cullin 9 Polyclonal Antibody
Cullin 9 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 적합하며, Human과 Mouse 시료에서 반응. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the carboxy terminus of human PARC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 2–8°C (up to 3 months); long-term storage at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155031 |
Product Specific Information
- Suggested positive control: Daudi cell lysate
- PA5-20277 can be used with blocking peptide PEP-0354.
Target Information
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor.
PARC, a large Parkin-like ubiquitin ligase, acts as a cytoplasmic anchor protein in p53-associated complexes.
Inactivation of PARC results in nuclear localization of p53 and activation of p53-dependent apoptosis, while its overexpression promotes cytoplasmic sequestration of p53.
PARC knockout mice are viable and show no obvious phenotype, suggesting functional redundancy with other cullin family E3 ubiquitin ligases.
p53 binding to PARC may serve to regulate PARC function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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