Thermo Fisher Scientific CD38 Monoclonal Antibody (90), eBioscience

Thermo Fisher Scientific CD38 Monoclonal Antibody (Clone 90), eBioscience

Applications and Tested Dilution

Product Specifications

Available Conjugate Formats

• Alexa Fluor 700
• APC
• APC-eFluor 780
• Biotin
• Brilliant UV 395
• Brilliant Violet 480
• Brilliant Violet 605
• eFluor 450
• FITC
• Functional Grade
• PE
• PE-Cyanine5
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Custom conjugation available upon request

Product Specific Information

The 90 monoclonal antibody reacts with mouse CD38, a ~42 kDa type II transmembrane protein. CD38 expression increases during B-cell differentiation and is down-regulated in germinal center B cells and mature plasma cells. It is also found on thymocytes, mature T cells, and NK cells. CD38 crosslinking induces B-cell proliferation, enhanced by IL-4 and LPS. CD38 acts as a counter-receptor for CD31 and functions as an ectoenzyme with cyclase and hydrolase activity, playing roles in lymphocyte activation and differentiation.

Applications Reported: Suitable for flow cytometry, immunohistochemistry, and functional assays. For functional assays, use Functional Grade purified 90 (Product #16-0381-85).

Applications Tested: Tested by flow cytometric analysis of mouse splenocytes at ≤0.125 µg/test (100 µL final volume). Recommended to titrate for optimal assay performance.

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes, and mediates apoptosis in progenitor cells. It functions as an ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD⁺ glycohydrolase) and as a cell surface receptor. Anti-CD38 antibodies are useful for lymphoma and leukemia subtyping, plasma cell detection (e.g., myelomas), and as markers for activated B and T cells. CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is highly expressed in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma. Associated diseases include chronic lymphocytic leukemia and Richter’s syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.