Thermo Fisher Scientific JAK3 Recombinant Rabbit Monoclonal Antibody (JM66-31)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:100

Product Specifications

Product Specific Information

This product is predicted to work in Western Blot at a dilution of 1:500–1:1,000.

Target Information

Janus kinase 3 (JAK3) phosphorylates members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to activation of interleukin receptors. In response to a variety of cytokines or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at two adjacent tyrosine residues. The activation of JAKs can lead to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Active JAK1 may be required for complex responses. Some studies suggest that the role of JAK2 might be performed by Tyk2 and JAK3 if positioned correctly within the IFN gamma-receptor complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.