Thermo Fisher Scientific TAK1 Recombinant Rabbit Monoclonal Antibody (JM73-19)
TAK1 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. Human 및 Mouse 시료 반응성. Protein A 정제, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM73-19 |
| Immunogen | Synthetic peptide within C-terminal human TAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898987 |
Target Information
TAK1 (MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, as well as responses to thyroid hormone, osmotic stress, and endothelin.
TAK1 regulates wound healing by promoting von Hippel-Lindau tumor suppressor expression and repressing PDGF-B, integrin β1, and β5. It is crucial for IKK activation in pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation involves TAB2/3 binding and ubiquitination, followed by TAK1 autophosphorylation and phosphorylation of IKK-β. TAK1 also represses human telomerase reverse transcriptase, implicating it in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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