Thermo Fisher Scientific HCCS Polyclonal Antibody
HCCS 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 Human, Mouse, Rat에 반응. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HCCS. Recombinant protein control fragment (Product #RP-92157) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642331 |
Product Specific Information
Immunogen sequence:
YVECPIRGTA AENKENLDPS NLMPPPNQTP APDQPFALST VREESSIPRA DSEKKWVYPS EQMFWNAMLK KGWKWKDEDI SQKDMYNIIR IHNQNNEQAW KEILKWEALH AAECPCGPSL IRFGGKAKEY SPRARIRSWM GYEL
Highest antigen sequence identity to the following orthologs:
- Mouse: 90%
- Rat: 92%
Target Information
CCHL (cytochrome c-type heme lyase), also known as HCCS (holocytochrome c-type synthase), is a 268 amino acid mitochondrial inner membrane protein belonging to the cytochrome c-type heme lyase family.
It contains two HRM (heme regulatory motif) repeats and is involved in the covalent linkage of a heme group to an apoprotein of cytochrome c.
The gene encoding HCCS is located on the human X chromosome.
Mutations in this gene cause microphthalmia syndromic type 7 (MCOPS7), also known as MIDAS syndrome or microphthalmia with linear skin defects (MLS), an X-linked male-lethal disorder resulting in eye deformation, microphthalmia, and linear skin defects in affected females.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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