Thermo Fisher Scientific Phospho-p38 MAPK (Thr180, Tyr182) Polyclonal Antibody
p38 MAPK의 Thr180/Tyr182 인산화 상태를 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF, Flow cytometry, ELISA에 적합. 다양한 종(Chicken, Goat, Human, Mouse, Rat)에 반응. Protein A 정제, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Goat, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human p38 MAPK around the phosphorylation site of Thr180/Tyr182 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motif. There are four isoforms of p38 MAPK, differing in tissue expression and affinity for upstream activators and downstream effectors. Upon exposure to stimuli such as tumor necrosis factor, interleukin-1, or heat shock, MAPK kinase-3/6 phosphorylates Thr180 and Tyr182 residues, activating p38 MAPK. Activated phospho-p38 MAPK subsequently phosphorylates transcription factors such as ATF-2, CHOP-1, and MEF-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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