Thermo Fisher Scientific Resistin Polyclonal Antibody
Thermo Fisher Scientific의 Resistin Polyclonal Antibody는 인간 Resistin 단백질을 인식하는 토끼 유래 IgG 항체입니다. Western blot, IHC, ELISA 등 다양한 응용에 적합하며, Protein A로 정제된 고순도 제품입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Resistin, amino acids 19–108 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adipose tissue serves as an energy reserve and is tightly regulated. Adipocytes produce and secrete several physiologically important proteins, including lipoprotein lipase (LPL), leptin, Acrp30, perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine secreted specifically by adipocytes. Although its function is not fully understood, resistin appears to play key paracrine roles and has been implicated in type 2 diabetes.
Studies in obese, diabetic mice show increased serum resistin levels, which antagonize insulin action. Resistin has been associated with insulin resistance and glucose intolerance in mice.
Expression of the resistin gene requires C/EBP alpha, aided by coactivators CBP and p300 that acetylate histones at the resistin promoter, activating chromatin for transcription. PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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