Thermo Fisher Scientific p23 Recombinant Rabbit Monoclonal Antibody (JU09-31)
Thermo Fisher Scientific의 p23 Recombinant Rabbit Monoclonal Antibody (JU09-31)은 인간, 마우스, 랫트 반응성을 가지며 WB, IHC, ICC/IF, IP에 사용 가능. HEK293 세포에서 발현된 고특이성 재조합 항체로 높은 로트 간 일관성과 민감도를 제공. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:10–1:50 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JU09-31 |
| Immunogen | Synthetic peptide within Human p23 aa 43–92 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810101 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Steroid receptors are ligand-dependent intracellular proteins that regulate transcription of specific genes upon hormone activation. Before activation, they form complexes with various proteins including HSP70, HSP90, immunophilins (FKBP52, FKBP54, CyP-40), and other co-chaperones such as p23, p60, and p48.
p23, a 160 amino acid phosphoprotein, interacts with HSP90 and is essential for the binding of HSP90 and CyP-40 to the progesterone receptor (PR). Although its exact function is not fully understood, p23 plays a crucial role in PR activity and steroid receptor complex formation.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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