Thermo Fisher Scientific Collagen Type I Polyclonal Antibody, HRP
콜라겐 타입 I에 특이적인 HRP 결합 폴리클로날 항체로, WB, IHC, ELISA 등 다양한 실험에 사용 가능. 인간 및 소 태반 유래 항원으로 제작되었으며, 높은 특이성과 낮은 교차반응성을 보임. 친화 크로마토그래피로 정제된 고순도 제품.
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Thermo Fisher Scientific Collagen Type I Polyclonal Antibody, HRP
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:3,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 5 µg/mL |
| ELISA | 1:3,000–1:6,000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Collagen Type I from human and bovine placenta |
| Conjugate | HRP |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 10 mg/mL BSA |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at 4°C prior to restoration. Restore with 0.05 mL of deionized water (or equivalent). For extended storage, aliquot contents and freeze at -20°C or below. Avoid freeze/thaw cycles. Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one year from date of restoration.
Typically negligible cross-reactivity against other types of collagens was detected by ELISA against purified standards.
This antibody reacts with most mammalian Type I collagens and shows negligible cross-reactivity with Type II, III, IV, V, and VI collagens.
Non-specific cross-reaction with other human serum proteins or non-collagen extracellular matrix proteins is negligible.
Target Information
Collagen I is a Type I collagen with a triple helix structure composed of two alpha-1 chains and one alpha-2 chain.
It is a member of group I collagen (fibril-forming collagen) found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome.
Reciprocal translocations between chromosomes 17 and 22, where Collagen Type I genes and the gene for platelet-derived growth factor beta are located, are associated with dermatofibrosarcoma protuberans.
Two transcripts, resulting from alternate polyadenylation signals, have been identified.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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